Welcome to our Clinical Insights page.
Clinical Practice Guidelines for Hypothyroidism in Adults:
Co-sponsored by the American Association of Clinical Endocrinologists and the American Thyroid Association
The American Association of Clinical Endocrinologists and American Thyroid Association Taskforce on Hypothyroidism in Adults reports that, "Treatment of hypothyroidism is best accomplished using synthetic T4 sodium preparations. Because of the uniqueness of the various tablet formulations and a recently introduced preparation of liquid containing capsules with the inactive ingredients gelatin, glycerin, and water, and because of uncertainty about the sensitivity of current bioequivalence assessment procedures to assure true interchangability among the tablets, current recommendations encourage the use of a consistent T4 preparation for individual patients to minimize variability from refill to refill."
"Some reports have indicated an apparent increased dosage requirement for T4 in some patients with diminished gastric acid secretion. This has led to in-vitro work showing significant differences in dissolution among T4 preparations, profiles of which appear to be dependent on the pH of the solution in which the preparations were dissolved. The liquicap preparation (Tirosint®) dissolution profile was the least affected by changes in pH."
Download the full Guidelines at http://aace.metapress.com/content/
Clinical Insights on T4 Therapy in a Liquid Gel Cap Form:
Could It Change Outcomes?
Here you can view a series of podcasts about Tirosint®, a unique, liquid gel cap formulation of levothyroxine for the treatment of hypothyroidism.
The podcasts feature presentations by noted endocrinologist Dr. Burton V. Caldwell.
You can also access a white paper, slide presentation, and a clinical reprint of the dissolution study by Pabla et al, discussed by Dr. Caldwell in his podcast presentation.
Click here to view reprint:
Dissolution study by Pabla et al
A noted clinical endocrinologist, Dr. Caldwell served on the faculty of Yale University as Associate Professor of Medicine from 1970 to 1980 and Attending Associate Professor of Medicine from 1980 to 2005. Dr. Caldwell was also a senior scientist at the Worcester Foundation from 1965 to 1970. He is the recipient of the National Science Foundation Award and the Career Development Award from the National Institutes of Health.